Publications:
1. Filip Janku, Sae-Won Han, Toshihiko Doi, Alessio Amatu, Jaffer A. Ajani, Yasutoshi Kuboki, Alex Cortez, Susan E. Cellitti, Ping C. Mahling, Kulandayan Subramanian, Heidi A. Schoenfeld, Sarah M. Choi, Lori A. Iaconis, Lang Ho Lee, Marc R. Pelletier, Glenn Dranoff, Vasileios Askoxylakis, Salvatore Siena. “Preclinical Characterization and Phase 1 Study of an Anti–HER2-TLR7 Immune-Stimulator Antibody Conjugate in Patients with HER2+ Malignancies.” Cancer Immunology Research. Published 2022.
2. Alex Cortez, Porino Va. “Recent Advances in Small-Molecule TLR7 Agonists for Drug Discovery.” Medicinal Chemistry Reviews.2018, 53, 481–500.
3. Alex Cortez, Yongkai Li, Andrew T. Miller, Xiaoyue Zhang, Kathy Yue, Jillian Maginnis, Janice Hampton, DeShon Hall, Michael Shapiro, Bishnu Nayak, Ugo D’Oro, Chun Li, David Skibinski, Lamine Mbow, Manmohan, Singh, Derek T. O’Hagan, Michel P. Cooke, Nicholas Valiente, Tom Y.-H. Wu. “Incorporation of phosphonate into benzonaphthyridine TLR7 agonists for adsorption onto aluminum hydroxide.”J. Med. Chem.2016, 59, 5868–5878.
4. Tom Y.-H. Wu, Manmohan Singh, Andrew T. Miller, Ennio De Gregorio, Francesco Doro, Ugo D’Oro, David A. G. Skibinski, M. Lamine Mbow, Simone Bufali, Ann E. Herman, Alex Cortez, et. al. “Rational design of small molecules as vaccine adjuvants.” Science Translational Medicine. 2014, 6, 1-12
5. G. A. Cortez, Richard R. Schrock, Amir H. Hoveyda. Angew. Chem. Int. Ed.2007, 46, 4534–4538.
6. G. A. Cortez, Carl A. Baxter, Richard R. Schrock, Amir H. Hoveyda. Org. Lett.2007, 9, 2871–2874.
7. Elizabeth S. Sattely, G. A. Cortez, David C. Moebius, Richard R. Schrock, Amir H. Hoveyda.
8. J. Am. Chem. Soc.2005, 127, 8526–8533. Gabriel S. Weatherhead, G. A. Cortez, Richard R. Schrock, Amir H. Hoveyda. Proc. Natl. Acad. Sci.2004, 101, 5805–5809. W. C. Peter Tsang, Jesper A. Jernelius, G. A. Cortez, Gabriel S. Weatherhead, Richard R. Schrock, Amir H. Hoveyda. J. Am. Chem. Soc.2003, 125, 2591–2596.
Patents and Patent Applications:
Additional patent applications being filed for Glue ALK degrader program.
1. Alex Cortez, Dahlia Weiss, Ryan Davison, Joshua Baughman. COMPOUNDS FOR THE DEGRADATION OF ALK PROTEINS. WO 2025/221826 A1, publication date October 23, 2025.
2. Lisa Barnett, Steven Bender, Alex Cortez, Sarah Cox, Jonathan Deane, Scott Martin Glaser, Ben Wen, Tom Yao Hsiang Wu. DC-SIGN ANTIBODY DRUG CONJUGATES. WO 2020/089811 A1, publication date May 7, 2020.
3. Alex Cortez, Timothy Hoffman, Yongkai Li, Tom Yao Hsiang Wu, Xiaoyue Zhang. COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS. US 10,407,431 B2. Date of Patent September 10, 2019.
4. Alex Cortez, Bernhard Hubert Geierstanger, Rodrigo Andreas Hess, Timothy Z. Hoffman, Shailaja Kasibhatla, Tetsuo Uno, Xing Wang, Tom Yao Hsiang Wu. ANTIBODY CONJUGATES COMPRISING TOLL-LIKE RECEPTOR AGONIST AND COMBINATION THERAPIES. WO 2018/198091 A1, publication date November 1, 2018.
5. Manmohan Singh, David Skibinski, Tom Yao Hsiang Wu, Yongkai Li, Alex Cortez, Xiaoyue Zhang, Yefen Zou, Timothy Hoffman, Jianfeng Pan, Kathy Yue. ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS. US 10,098,949 B2. Date of Patent October 16, 2018.
6. Alex Cortez, Bernhard Hubert Geierstanger, Timothy Z. Hoffman, Shailaja Kasibhatla, Tetsuo Uno, Xing Wang, Tom Yao Hsiang Wu. ANTIBODY CONJUGATES COMPRISING TOLL-LIKE RECEPTOR AGONIST. WO 2017/072662 A1, publication date May 4, 2017.
7. Tom Yao Hsiang Wu, Yongkai Li, Alex Cortez, Kathy Yue, Yefen Zou, Pranab Mishra, Xiaoyue Zhang, Manmohan Singh, David Skibinski, Nicholas Valiente. COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS. US 8,895,577 B2, Date of Patent: November 25, 2014. US 8,466,167 B2, Date of Patent: June 18, 2013.